1 1 Calcium - permeable ion channels in the kidney
نویسندگان
چکیده
1 Calcium-permeable ion channels in the kidney 2 3 4 5 Yiming Zhou and Anna Greka 6 7 8 9 10 Department of Medicine and Glom-NExT Center for Glomerular Kidney Disease and 11 Novel Experimental Therapeutics, Brigham and Women’s Hospital and Harvard Medical 12 School, Boston, Massachusetts, USA; and 2 The Broad Institute of MIT and Harvard, 13 Cambridge, MA, USA. 14 15 16 Correspondence information: 17 Anna Greka, M.D., Ph.D., Renal Division, Brigham and Women’s Hospital, Harvard 18 Medical School, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, 19 Massachusetts 02115, Tel.: (617) 525-5939, Fax: (617) 525-5965, E-mail: 20 [email protected] 21 22 23 24 25 26
منابع مشابه
Calcium-permeable ion channels in the kidney.
Calcium ions (Ca(2+)) are crucial for a variety of cellular functions. The extracellular and intracellular Ca(2+) concentrations are thus tightly regulated to maintain Ca(2+) homeostasis. The kidney, one of the major organs of the excretory system, regulates Ca(2+) homeostasis by filtration and reabsorption. Approximately 60% of the Ca(2+) in plasma is filtered, and 99% of that is reabsorbed by...
متن کاملSolubilized proteins from carrot (Daucus carota L.) membranes bind calcium channel blockers and form calcium-permeable ion channels.
Calcium channels have been suggested to play a major role in the initiation of a large number of signal transduction processes in higher plant cells. However, molecular components of higher plant Ca2+ channels remain unidentified to date. Calcium channel blockers of the phenylalkylamine family and bepridil specifically inhibit Ca2+ influx into carrot (Daucus carota L.) cells. By using a phenyla...
متن کاملAnnexin-Mediated Calcium Signalling in Plants.
Calcium-permeable channels underpin elevations of free calcium that encode specific signals in stress adaptation, development and immunity. Identifying the genes encoding these channels remains a central goal of plant signalling research. Evidence now suggests that members of the plant annexin family function as unconventional calcium-permeable channels, with roles in development and stress sig...
متن کاملCalcium-permeable ion channels in pain signaling.
The detection and processing of painful stimuli in afferent sensory neurons is critically dependent on a wide range of different types of voltage- and ligand-gated ion channels, including sodium, calcium, and TRP channels, to name a few. The functions of these channels include the detection of mechanical and chemical insults, the generation of action potentials and regulation of neuronal firing...
متن کاملCalcium-permeable ion channels in control of autophagy and cancer
Autophagy, or cellular self-eating, is a tightly regulated cellular pathway the main purpose of which is lysosomal degradation and subsequent recycling of cytoplasmic material to maintain normal cellular homeostasis. Defects in autophagy are linked to a variety of pathological states, including cancer. Cancer is the disease associated with abnormal tissue growth following an alteration in such ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2016